US-12 (Michigan Avenue) through Saline follows the route of the historic Sauk Trail, a Native American trail that was to later become the Detroit and Chicago Road. Orange Risdon the founder of Saline was the original surveyor for the Detroit and Chicago Road. The portion of Michigan Avenue in Saline designated as a Heritage Route has several historic attractions. The old Schuyler Mill (now Weller's) is located near the intersection of US-12 and the Saline River. Henry Ford converted this Mill in 1937 to a soybean processing plant for the manufacture of auto paint and auto parts. The Saline downtown area is historically significant and vibrant. Oakwood Cemetery, Curtiss Mansion and the Rentschler Farm museum are other important attractions.

US-12 in Clinton and Clinton Township are part of the historic Saulk Trail. Typically, Clint was founded on the convergence of a road, the Chicago Military Road and a river, The Raisin. The original community was called Oak Opening because of its location in a natural opening in the dense oak forest. Clint soon became the greatest trading point west of Detroit with then general stores, several blacksmith shops, a hardware store, the Clinton Inn, Atlas Mill, and the Clint Woolen Manufacturing Company with 200 employees. Today many of the buildings in the Village of Clinton and Clinton Township are faithfully preserved, but with modern conveniences to better serve today's customer.